The 33-year-old defender made 315 appearances for Spurs, but decided to leave the Jose Mourinho side after seeing his playing time limited under the new manager this season.
The Belgian, who departs as a free agent, helped Spurs reach finals in the Champions League and League Cup.
Vertonghen, who joined Tottenham from Ajax in 2012 disclosed his departure on his official Twitter page on Monday morning.
“So my time at the club comes to an end. A sad day for many reasons. I will miss the friends I’ve made here, the staff that make the club run, playing at the amazing new stadium & of course you fans.”
“Thank you for all the support over the years. You’ve been amazing. We had many unbelievable memories but for now, it’s goodbye.”
— Jan Vertonghen (@JanVertonghen) July 27, 2020
His team-mate and England striker – Harry Kane, was among those to pay tribute to him, saying;
— Harry Kane (@HKane) July 26, 2020