Two second half goals from Raul Jimenez and Diogo Jota was all Wolves needed at Molineux to humble and send the Red Devils parking out FA Cup.
Wolves secured a 2-1 victory over United during their FA Cup quater-final clash to progress to the next stage for the first time since 1998.
It was a beautiful display from the home side on Saturday night as they dominated the entire game.
Raul Jimenez broke the deadlock for Wolves in the 70th minute with a crisp strike before Diogo Jota grabed the second goal six minutes later with a powerful drive through Sergio Romero.
However, Marcus Rashford pulled one back at the death, but it was already too late for United.
Wolves, Manchester City, Watford and either Brighton and Hove Albion or Millwall will advance to the last four of the competition.
After the international break, Wolves will face Burnley at home in their Premier League clash while Manchester United will battle Watford at Old Trafford.